Signant’s neuroscience team and CNS experts presented scientific posters at the 2022 Autumn Conference hosted by the International Society for CNS Clinical Trials and Methodology.  

The posters presented original research on a variety of topics related to the Positive and Negative Syndrome Scale (PANSS), including the potential impact of baseline PANSS symptom domain severity on interview duration and abnormal patterns of variability such as post-baseline 30/30 PANSS identical ratings. Separately, we examined whether a 10-item PANSS optimized for pediatric trials would perform similarly to the 30-item PANSS in an independent placebo-controlled multi-site trial. 

Other posters delved into research on the Mini-Mental State Exam (MMSE) for dementia, including the association between the MMSE interview duration and the presence of administration and/or scoring errors, and the impact of the number of per rater MMSE administrations on the probability of identifying an administration or scoring MMSE error. 

Browse through each poster below and meet our experts to learn how Signant has been optimizing CNS clinical research for over 20 years.  

Signant Health

Signant Health is the evidence generation company. We are focused on leveraging software, deep therapeutic and scientific knowledge, and operational expertise to consistently generate quality evidence for clinical studies across traditional, virtual, and hybrid trial models. For more than 20 years, over 400 sponsors and CROs of all sizes – including all of Top 20 pharma – have trusted Signant Health solutions for remote and site-based eCOA, eConsent, IRT, supply chain management, and data quality analytics.

Recent Posts

Clinical Supplies

Application Programming Interfaces (APIs) in Randomization and Trial Supply Management (RTSM)

Learn more

Scientific Advisory

AAIC 2022: Scientific Posters Compilation

Learn more

eCOA

5 Recommendations for Electronically Migrating and Implementing ClinROs

Learn more

eCOA

Innovation: Using Smartphone Sensors to Instrument At-Home Stair-Climbing Performance Tests

Learn more

Scientific Advisory

Get to Know the SME – Lew Fredane

Learn more