About Us

Real time has become real life, especially for those of us who run clinical trials.

See the SignalsSeize the Data

Real time has become real life, especially for those of us who run clinical trials.

See the Signals

The evidence generation company™

The speed, quality, and integrity of endpoint evidence is everything in being able to efficiently advance an experimental therapy forward.

Signant is the evidence generation company that helps you digitally enable trials. No matter how or where you run your trials.

We make the patient journey more natural and intuitive, and the data journey more direct and objective.

With the Signant SmartSignals ecosystem, Signant delivers proof at the speed of life, simplifying and streamlining data generation and reducing the reliance on paper-based evidence gathering and management.

We offer vision at a time of change as well as reliability and dependability where it matters most.

When the world is counting on you, count on Signant.

Signant Health’s Regulatory Approvals Since 2016:​

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Our 20-year history


Signant achieves milestone of supporting supporting 28% of all novel drug approvals in the U.S and Europe between 2016 and 2021.

Signant Health acquires VirTrial to enhance its digital enablement of clinical research sites and evidence generation capabilities.

The combined company grows more in the first quarter together than either company achieved alone in 2018.

CRF Bracket launches as Signant Health, a unified patient technology organization focused on making it easier for sponsors and CROs to change patients’ lives.


Genstar Capital acquires and combines CRF Health with Bracket to become CRF Bracket, delivering industry-leading, patient-centric technology that improves the speed, reliability, and insight of clinical research.


Bracket acquires mProve Health to radically advance patient engagement in clinical trials.

Bracket releases a transformative interactive response technology (IRT) solution for the life sciences industry.


CRF Health achieves one million monthly patient interactions.


Bracket is created through the merger of the Specialty Clinical Services and Clinical Technologies Group business units within United BioSource Corporation (UBC).


PharmaStar LLC, the predecessor to Bracket Global LLC, is founded.


CRF Health, formerly known as CRF Inc., is founded.