Historically, the primary endpoints for oncology studies have been the tumor response and survival rate. However, there is a growing interest in clinical research for patient-centricity. Patient-reported outcomes (PROs) offer meaningful data from the patient’s point of view that can inform regulators on the treatment experience. Daily diaries can record PROs like symptoms more reliably than infrequent, on-site assessments that require patients to recall. Data analytics can be applied to further monitor the quality of the data to ensure quality. Today’s advanced software can build stronger site-patient relationships, reduce dropout rates, and deliver accurate data.