This article discusses the need for patient engagement technologies in clinical research. Before choosing a patient engagement tool though, sponsors should first consider the patient population, the study’s goals, and their organization’s structure. Once you decide on the best patient engagement solution, you’ll need to know how to measure the tool’s success. It’s important to monitor: Patient retention rates Protocol deviations Improved adherence Diary completion rates But how do you get patients to use the digital engagement solution? We share some recommendations.