Signant Health’s Rater Training & Central Rating services played a key role in a sponsor’s movement disorder trial by optimizing signal detection of a primary endpoint. This endpoint was measured using clinician ratings of abnormal, involuntary movements in patients with tardive dyskinesia.

Our services helped investigators deliver a consistent, standardized set of tests for the Abnormal Involuntary Movement Scale (AIMS). Our blinded central video raters then assessed the change in AIMS score from baseline to week 12 to ensure accuracy.

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