Signant’s Central Rating Services Improved Signal Detection in 5 Major Depressive Disorder Trials

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Case Study

Signant Health’s Central Rating services played an important role in five clinical trials for major depressive disorder (MDD) by helping to ensure consistent, accurate scoring of site-based assessments. Our raters compared paired, site-independent scores derived from audio recordings of Montgomery-Asberg Depression Rating Scale (MADRS) interviews to the original site-based ratings. This method of quality control gave insight into the reliability of site ratings and provided feedback that would improve through-study accuracy.

In each of these trials, central raters optimized signal detection of treatment-related differences, mitigated inter-rater and intra-rater variability, and enabled opportunities for rater remediation.

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