Signant’s Central Rating Services Improved Signal Detection in 5 Major Depressive Disorder Trials Date Published: Feb 01, 2023 Case Study Signant Health’s Central Rating services played an important role in five clinical trials for major depressive disorder (MDD) by helping to ensure consistent, accurate scoring of site-based assessments. Our raters compared paired, site-independent scores derived from audio recordings of Montgomery-Asberg Depression Rating Scale (MADRS) interviews to the original site-based ratings. This method of quality control gave insight into the reliability of site ratings and provided feedback that would improve through-study accuracy. In each of these trials, central raters optimized signal detection of treatment-related differences, mitigated inter-rater and intra-rater variability, and enabled opportunities for rater remediation. Read our case study for more details. Learn More Share: LinkedInTweet Recommended Resources Central Clinical Ratings Solution Download Now Brochure Video Major Depressive Disorder Research Solutions As the evidence generation company, Signant advises study teams on navigating unique challenges. Our SmartSignals solutions can simplify major depressive... Watch Now Signant’s Rater Training and Central Rating Services Optimized Signal Detection in Movement Disorder Trial Read More Case Study