Clinical trial data must be maintained in a separate, compartmentalized database, but this poses a problem to those managing hundreds of studies at once. This Applied Clinical Trials article explores strategies for scaling up amidst the recent COVID-19 pandemic, and what this means for the future of clinical research. Popular countermeasures addressing COVID-related challenges include reimagining how site monitoring is conducted and enabling decentralized trials with technology. Experts also weigh in on the benefits of transitioning from on-site trials to at-home assessments, how to keep regulators\u2019 support, and the growing importance of digital health. Find out essential next steps to prepare for the industry\u2019s new norm in this PharmaVOICE article.